30L 300L Fully Automatic Fermentation Bioreactor for Vaccine Process
The 30L 300L fully automatic fermentation bioreactor is a high-performance system designed for precise and contamination-free bacterial vaccine production. Engineered for pharmaceutical and biotechnology applications, this advanced fermentation bioreactor ensures stable operation, accurate control, and consistent product quality.
Built with a fully sealed design, the system eliminates leakage and prevents contamination, making it ideal for sensitive biological processes.
Advanced Design for Safe and Reliable Operation
This fermentation bioreactor is designed with a compact and integrated structure, allowing all essential components to work seamlessly within a single system.
Leak-Proof and Contamination-Free System
- Fully sealed tank design with zero leakage
- Double mechanical sealing to prevent contamination
- Maintenance-free operation for long-term reliability
The system supports both top-driven mechanical stirring and bottom magnetic stirring, providing flexibility for different process requirements.
High-Quality Tank Construction
The tank is manufactured using premium materials to meet strict hygiene and durability standards.
Material and Structure
- Tank body: 316L stainless steel
- Inner surface polishing: Ra ≤ 0.4
- Diameter to height ratio: 1:1 to 2.5
- Filling capacity: up to 70%
This ensures easy cleaning, corrosion resistance, and a hygienic production environment.
Intelligent Monitoring and Control System
The fermentation bioreactor is equipped with an advanced control system that enables real-time monitoring and precise control of critical parameters.
Key Monitoring Parameters
- pH level
- Dissolved Oxygen (DO)
- Temperature
- Stirring speed
- Airflow and pressure
All data can be transmitted to a computer system for analysis, process optimization, and performance tracking.
KNIKBIO-D Smart Control System
The system uses a Siemens S7-200 PLC-based control platform with a 12-inch touchscreen interface.
Control Features
- User-friendly operation with full English interface
- Real-time data monitoring and display
- Historical data analysis and curve tracking
- Easy calibration of pH and DO sensors
- Remote data transmission and integration
Efficient Mixing and Aeration System
Proper mixing and oxygen supply are essential for successful fermentation processes.
Mixing System
- Multi-stage straight and pitched blade design
- Stirring speed: 50–1000 RPM (stepless control)
- Accuracy: ±1 RPM
Aeration System
- Multi-channel ventilation
- Thermal mass flow meter for precise airflow control
- Automatic adjustment of air and oxygen supply
Accurate Process Control Functions
pH Control
- Range: 2–12 pH
- Accuracy: ±0.02 pH
- Automatic acid and alkali dosing
Dissolved Oxygen (DO) Control
- Range: 0–100%
- Accuracy: ±3%
- Controlled via airflow, pressure, and agitation
Temperature Control
- Range: +5°C to 80°C
- Accuracy: ±0.1°C
- Electric heating with water cooling system
Sterilization, Cleaning, and Safety Systems
Maintaining sterility is critical in vaccine production, and this fermentation bioreactor includes advanced safety features.
Integrated Systems
- SIP (Sterilization-In-Place) automatic system
- Optional CIP (Cleaning-In-Place) system
- Intake sterilization filter and exhaust condenser
- Exhaust gas treatment with heating, filtration, and inactivation
Automated Feeding and Foam Control
The system includes a complete automated feeding setup to ensure continuous and stable fermentation.
Feeding System
- Acid and alkali solutions
- Culture media
- Antifoam agents
Foam Control
- Automatic foam detection
- Peristaltic pump-based defoaming system
Optional Features for Enhanced Performance
- Fermentation broth weighing system with load cell
- Automatic tank lid lifting system for easy maintenance and cleaning
Why Choose This Fermentation Bioreactor
The 30L 300L fully automatic fermentation bioreactor is an ideal solution for manufacturers seeking precision, efficiency, and reliability.
Key Benefits
- Fully sealed and contamination-free design
- High-precision PID control system
- Advanced PLC automation
- Durable and hygienic stainless steel construction
- Easy maintenance and operation
- Ideal for vaccine production and biotech applications
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